Detection of Potential Markers for Lip Vermilion Epithelium in Japanese Macaques Based on the Results of Gene Expression Profile

Development of effective in vitro human lip models, specific to the vermilion epithelium, has not progressed as much that skin and oral mucosa/gingiva models vitro. Our histologic examination demonstrated a Japanese macaque (male, 7 years 9 months old) had distinct from adjacent mucosa, resembling histological characteristics lip. Therefore, this study, we examined gene expression profile three epithelia (skin/vermilion/oral mucosa) within explore single potential marker epithelium. Six pairwise comparisons skin/vermilion/oral mucosa epithelium vivo revealed 69 differentially up-regulated genes vivo, which few unique were highly expressed when compared with both using clustering analysis. However, could detect supported by macaque. Instead, pair keratin 10 small proline-rich protein 3 resulted (female, 53-year-old) via double-immunostaining technique. Nonetheless, our result may provide further clues leading other markers